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A P P E N D I X A
What About the Widely Advocated Dietary Restrictions on Fat, Protein, and Salt, and the Current High-Fiber Fad?

Most of this book is instructional, of the how-to variety. The intent of this appendix is to provide you with a little of the science that surrounds the program described in the rest of the book. With respect to a number of the issues raised in this section, I would also refer you again to Gary Taubes’s award-winning Science article “The Soft Science of Dietary Fat, ”which is available on the Web site for this book, www.diabetes-book.com/articles/ssdf.shtml, or from the March 2001 edition of the journal Science. Another masterpiece by Taubes, “What If It’s All Been a Big Fat Lie?,” appeared as the cover article in the New York Times Magazine of July 2, 2002. It can also be found on this book’s Web site.

I hope that I can cut through some of the myths that cloud diet and the treatment of diabetic complications so that you will have the why that supports the how-to. We’ve already discussed some of the myths. We’ll look at the origins of those myths to try to give you as many of the facts as are available at this writing. If your only interest is in the how-to, feel free to skip this appendix.

Once you’ve started to follow a restricted-carbohydrate diet, you may find yourself pressured by well-meaning but uninformed friends or family, or even newspaper articles, to cease penalizing yourself and eat more “fun” foods—sweets, bread, pasta, and fruits. This chapter will provide you with specific scientific information that underpins my approach and will perhaps give you some ammunition for responding to this pressure. Even if you skip it now, you may want to come back to it later, or show it to your loved ones to lay their concerns to rest. As I don’t expect most readers to be scientists, I’ve tried to keep all these explanations relatively simple. Some of the explana- tions may at this moment represent more theory than fact, but they’re based on the latest information available to us.

HOW DID THE COMMONLY PRESCRIBED HIGH-CARBOHYDRATE DIET COME ABOUT?

If, like me, you’ve had diabetes for a while, you’ve probably been told to cut way down on your dietary intake of fat, protein, and salt, and to eat lots of complex carbohydrate. You may even still read this advice in publications circulated to diabetic patients.

Why is such advice being promulgated, when the major cause of such diabetic complications as heart disease, kidney disease, high blood pressure, and blindness is high blood sugar?

When I first developed diabetes, in 1946, little was known about why this disease, even when treated, caused early death and such distressing complications. Prior to the availability of insulin, about twenty-five years earlier, people with type 1 diabetes usually died within a few months of diagnosis. Their lives could be prolonged somewhat with a diet that was very low in carbohydrate and usually high in fat. Most sufferers from the milder type 2 diabetes survived on this type of diet,without supplemental medication. When I became diabetic, oral hypoglycemic agents were not available, and many people were still following very low carbohydrate, high-fat diets. It was at about this time that diets very high in saturated fats, with resultant high serum cholesterol levels, were experimentally shown to correlate with blood vessel and heart disease in animals. It was promptly assumed by many physicians that the then-known complications of diabetes, most of which related to abnormalities of large or small blood vessels, were caused by the high-fat diets. I and many other diabetics were therefore treated with a high-carbohydrate, low-fat diet. This new diet was adopted in the mid-1940s by the American Diabetes Association (ADA), the New York Heart Association, and eventually by the American Heart Association (AHA) and other groups around the world. On the new diet, most of us had much higher serum cholesterol levels, and still developed the grave long-term complications of diabetes. Seemingly unaware of the importance of blood sugar control, the ADA raised the recommended carbohydrate content from 40 to 50 percent of calories, and then more recently to 60 percent. The ADA’s most recent guidelines have backed off by vaguely stating that some diabetics may do better with less carbohydrate.

RECENT DEVELOPMENTS REGARDING RISK FACTORS FOR HEART DISEASE

In the past twenty years, research studies have generated considerable new information about heart disease and vascular (blood vessel) disease in general, and their relationship to diabetes in particular. Some of this more recent information is summarized here.

A number of substances have been found in the blood which relate to risk of heart attacks and vascular disease. These include HDL (highdensity lipoprotein), LDL (low-density lipoprotein), triglyceride, fibrinogen, homocysteine, C-reactive protein, and lipoprotein(a). High serum levels of LDL, triglyceride, fibrinogen, homocysteine, C-reactive protein, and lipoprotein(a) tend to be associated with increased cardiovascular risk, while high levels of HDL tend to protect from cardiovascular disease. Cholesterol is a component of both LDL and HDL particles. The fraction of total cholesterol found in LDL particles is an index of risk, while the fraction of cholesterol found in HDL particles is an index of protection. Nowadays, when we want to estimate the effects of lipids (fatty substances) upon the risk of coronary artery disease, we look at the ratio of total cholesterol to HDL and also at fasting triglyceride levels. Someone with high serum HDL can thus have a high total cholesterol and yet be at low statistical risk for a heart attack. Conversely, a person with low total cholesterol and very low HDL may be at high risk.

A large multicenter study (the Lipid Research Clinics Trial) investigated the effects of a low-fat, high-carbohydrate diet versus a high-fat, low-carbohydrate diet on nondiabetic middle-aged men with elevated cholesterol levels. The study followed 1,900 people for seven years. Throughout this period, total cholesterol had dropped only 5 percent from baseline in the low-fat group, but serum triglyceride went up about 10 percent! (Serum triglyceride rises very rapidly after a highcarbohydrate meal in nondiabetics, and moves up and down with blood sugar levels in most diabetics.) As with prior studies, no significant correlation was found between serum cholesterol levels and mortality rates. Furthermore, a study reported in the Journal of the American Medical Association in 1997 showed that a 20 percent increase in either saturated or monounsaturated dietary fat lowered the risk of stroke to one-eighth of what it was in individuals on lower-fat
diets. Unsaturated fats showed no such benefit.

On average, diabetics with chronically high blood sugars have elevated levels of LDL (the “bad” cholesterol) and depressed levels of HDL (the “good” cholesterol), even though the ADA low-fat diet has now been in use for many years. Of great importance is the recent discovery that the forms of LDL that harm arteries are small, dense LDL, oxidized LDL, and glycated LDL. All of these increase as blood sugar increases. In addition, independently of blood sugars, high serum insulin levels dictated by high-carbohydrate diets bring about increased production of small, dense LDL particles and enlargement of the cells lining the arteries.

Under normal conditions, receptors in the liver remove LDL from the bloodstream and signal the liver to reduce its manufacture of LDL when serum levels rise even slightly. Glucose may bind to the surface of the LDL particle and also to liver LDL receptors, so that LDL cannot be recognized by its receptors. In people with high blood sugars, many LDL particles become glycosylated, and are therefore not cleared by the liver. This glycosylation is reversible if blood sugar drops. After
about 24 hours, however, a rearrangement of electron bonds occurs in glycosylated proteins, so that the glucose can’t release even if blood sugar drops. This irreversible glycosylation is called glycation, and the affected protein molecules are said to be “glycated.” They are also referred to as AGEs, or advanced glycosylation end products. These AGEs accumulate in the blood, where they can become incorporated into the walls of arteries, forming fatty deposits called atherotic plaques. Since liver LDL production cannot be turned off by the glycosylated/ glycated LDL (and also the presence of glycosylated/glycated LDL receptors), the liver continues to manufacture more LDL, even though serum levels may be elevated.

The proteins in the walls of arteries can also become glycosylated/ glycated, rendering them sticky.Other proteins in the blood then stick to the arterial walls, causing further buildup of plaque. Serum proteins glycosylate in the presence of glucose.White blood cells called macrophages ingest glycosylated/glycated proteins and glycosylated/ glycated LDL. The loaded macrophages swell up, becoming very large. These transformed macrophages, loaded with fatty material,
are called foam cells. The foam cells penetrate the now sticky arterial walls, causing disruption of the orderly architecture of the artery, and narrow the channel through which blood can flow.

The middle layer of the walls of large arteries contains smooth muscle cells that can invade the fatty coating (plaque) that these cells create. They then prevent the plaque from breaking loose. When the nerves that control this smooth muscle die, as in diabetic autonomic neuropathy (caused by high blood sugars), the muscle layer dies and calcifies. It then cannot prevent plaque rupture. When a piece of ruptured plaque enters the blood it can block narrow vessels upstream
and cause a heart attack.

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Quick Reference
This quick index helps you zoom in on chapter/article references dealing with a symptom or complication of diabetes. There may be other references throughout the site; always read the paragraphs or pages surrounding the reference in order to obtain proper context. A key to abbreviations is featured at the bottom of the chart.
 

amputation Ch.1
anemia B&A
arm pain B&A
arthritis B&A
cardiomyopathy /
cardiovascular disease
50yrs Ch.1 AppA 
cardiac neuropathy B&A B&A
cataracts / blindness 50yrs Ch.1 Ch.1 Ch.1 B&A App.A Articles
convulsions B&A
diarrhea, chronic Articles Articles
digestive problems B&A
erectile dysfunction (impotence) Ch.1 B&A B&A Ch.23
fatigue / fainting B&A B&A
feet, general App.E Articles Articles
feet, altered gait B&A Articles
feet, deformity 50yrs
feet, neuropathy B&A B&A B&A Ch.23 Articles Articles
feet, numbness B&A B&A
feet, pain Ch.1 B&A B&A
feet, scaly B&A
feet, ulcers B&A Articles
flatulence B&A
frozen shoulder 50yrs Ch.1
glaucoma B&A Articles
gluconeogenesis Ch.1
hand numbness B&A 
heart attack / blood clots Ch.1 App.A
headaches B&A
heart / arterial disease B&A B&A App.A
heartburn / belching / gastroparesis B&A Articles Articles
high cholesterol 50yrs B&A
hypertension / high blood pressure Ch.1 App.A App.A Ch.23 Articles Articles
hyperglycemia Ch.9
hyperinsulinemia Ch.1
hypoglycemia 50yrs 50yrs B&A B&A B&A Ch.1 Ch.9 Articles Articles Articles
ilio-tibial band/tensor fascia lata syndrome 50yrs
impaired glucose tolerance (IGT) Ch.1
joint inflammation / tightness Ch.1
ketoacidosis 50yrs B&A Articles Articles
kidney stones / kidney disease / nephropathy / infections 50yrs Ch.1 B&A B&A B&A B&A App.A App.A App.A Ch.9 Articles
leg pain B&A
macular edema 50yrs
microaneurysms 50yrs 50yrs
mood changes B&A
night blindness 50yrs
nerve damage Ch.1 Ch.1
obesity / weight gain B&A B&A B&A B&A  Ch.1 Ch.1 Ch.12 Articles
osteoporosis Ch.1
periodontal disease  Articles
peripheral vascular disease 50yrs
proteinuria 50yrs 50yrs
retinopathy Ch.1 B&A
salivary duct stones 50yrs
short-term memory loss / loss of mental activity  B&A Articles
skin tightness / skin conditions Ch.1 B&A
sleepiness B&A
sweating B&A B&A
thirst B&A
twitching limbs B&A
ulcers B&A
vision changes / diseases B&A B&A B&A B&A Ch.23 Articles Articles Articles

50yrs: "My First 50 Years as a Diabetic"
B&A: "Before & After: 14 Patients Share Their Experiences"
Ch.1: "Chapter 1", etc.
App.A: "Appendix A", etc.
Articles: References an item in the "Articles" section of the site.


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