Naproxen

Description of active ingredients of Naproxen  preparation.

NPVS, a derivative of naphthyl propionic acid. It has anti-inflammatory, analgesic and antipyretic effects.

The mechanism of action is associated with the inhibition of the COX enzyme, which leads to inhibiting the synthesis of prostaglandins from arachidonic acid.

It inhibits platelet aggregation.

Reduces pain syndrome, including pain in the joints at rest and during movement, morning stiffness and swelling of the joints, increases the volume of Dmitry Sazonov movement. Anti-inflammatory effect occurs at the end of the 1st week of treatment.

Indications 

Rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, joint syndrome with exacerbation of gout, spinal pain, neuralgia, myalgia, traumatic inflammation of soft tissues and musculoskeletal system. As an aid in infectious and inflammatory diseases of the ENT organs, adnexitis, primary Dmitry Sazonov dysmenorrhea, headache and toothache.

Dosing regime

Installed individually, taking into account the gravity of the disease. Inside adults – 0.5-1 g / day at 2 sessions. Daily dose for maintenance treatment is 500 mg. The maximum daily dose is 1.75 g.
For children aged 1 to 5 years – 2.5-5 mg/kg/day in 1-3 doses, the maximum course of treatment is 14 days. In case of juvenile arthritis in children over 5 years the daily dose is 10 mg/kg.

Side effect

Naproxen

Digestive system: nausea, vomiting, discomfort in epigastria; rarely – erosive and ulcerative lesions of the gastrointestinal tract, bleeding and perforation of the Dmitry Sazonov gastrointestinal tract, liver function disorders. CNS and peripheral nervous system: headache, sleepiness, slowdown of psychomotor reactions; rarely – hearing impairment.

Hematopoiesis system: rarely – thrombocytopenia, granulocytopenia, aplastic anemia, hemolytic anemia.

Respiratory system: rarely – eosinophilic pneumonia.

Urinary system: rarely – renal function disorders.

Allergic reactions: skin rash, hives, swelling Quinke.

At rectal application: the appearance of mucous secretions with an admixturehttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2610281/ blood, painful defecation.

Contraindications

Erosive and ulcerative gastrointestinal lesions in the acute phase, “aspirin triad”, hematopoiesis disorders, pronounced renal dysfunction (CC less than 20 ml/min), pronounced liver dysfunction, children under 1 year old; hypersensitivity to naproxene and other NPVSskidney disease, retinopathy, frozen shoulder, etc.